The Okwahu Campus is located at the town of Abetifi, one of the seventeen original towns (Nkrotoo) of the people of Okwawu at the southern part of the Okwawu-Mampong ridge in the Eastern Region of Ghana. The Abetifi section of the ridge forms the highest inhabited location in Ghana at about 630 m (2080 ft) above sea level. It has the desirably cool and pleasant climate (average 25oC) associated with elevated locations in the tropics. The seventeen towns are clustered together at an average distance of four kilometres from each other and about 180 km from Accra (Ghana’s capital) and 130 km from Kumasi (second capital). The cluster is within a radius of 6 km. The gateway is through a metropolitan town of Nkawkaw at the foot of the ridge on the Accra-Kumasi highway with a population of 45,000.
Abetifi is one of the early Basel Mission stations in the country. The Basel Missionary Reverend F.A. Ramseyer and his wife were taken through Abetifi as captives of war (one of the Asante-European wars) on the way to Kumasi in 1869. Rev. Ramseyer later returned to Abetifi to establish a mission station and a school in 1876. The church and the Ramseyer Lay Training Centre today mark the enduring presence of the Presbyterian Church in the town. The Ramseyer Training Centre is currently sharing space with the College on land that was given to Rev. Ramseyer.
The resident population of Abetifi, about 15,000, is engaged in farming, fishing, livestock rearing, crafts and trading. The local economy is supported by a large semi-resident business population in the large urban towns in all the regions of Ghana. With the exception of the regional capitals in the country, Abetifi is well endowed with various educational institutions with several primary and secondary schools, technical and vocational schools, and a high ranking training college.